吴帼英

个人简介

吴帼英，教授，“动物应激与疾病校级重点实验室”主任，山东师范大学硕士生导师，betway必威“高层次引进人才”。2000年毕业于山东师范大学，获理学学士学位；2007年毕业于日本东京大学，获博士学位。2007-2012年，在东京大学做博士后研究。2012-2014年在日本TaKaRa Bio Inc.担任技术总监。主要从事自身免疫性疾病表观遗传学调控机制研究。现为中国非公立医疗机构协会生物技术与细胞应用专业委员会常务委员、中国生态风险分析专业委员会理事、山东省动物学学会理事、中国免疫学学会会员。

研究方向

1. 胸腺上皮细胞异位基因表达调控机制与自身免疫性疾病

2. 体液microRNA在疾病分子诊断中的应用研究

主持和参与课题

1.胸腺上皮细胞中异位基因表达的DNA甲基化调控机制研究（31700787），国家自然科学基金，主持，2018.01-2020.12 ，48万元

2.血浆和尿液microRNA在小儿过敏性哮喘早期诊断中的应用研究（20152DL02），betway必威校内重大研究项目，主持，2016.06-2019.06，5万元

3.体液microRNA在小儿过敏性哮喘早期诊断中的应用研究（J15LE06）山东省高等学校科技计划，主持，2015.07-2018.06 ，6.9万元

发表论文

1. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demizu, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef Penninger, Yasuhiro Kobayashi, Jun-ichiro Inoue, and Taishin Akiyama. J Exp Med. 2016 Jul 25;213(8):1441-58.

2. Akiyama N, Shinzawa M, Miyauchi M, Yanai H, Tateishi R, Shimo Y, Ohshima D, Matsuo K, Sasaki I, Hoshino K, Wu G, Yagi S, Inoue J, Kaisho T, and Akiyama T, Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation, J Exp Med. 2014 211:2425-38

3. Wu G, Hirabayashi K, Sato S, Akiyama N, Akiyama T, Shiota K, and Yagi S, DNA methylation profile of mouse medullary thymic epithelial cells. BMC Immunology. 2012 13:58

4.Nakajima K, Wu G, Sakudo A, Onodera T, and Takeyama N. Distinct subcellular localization of three isoforms of insulinoma-associated protein 2ß in neuroendocrine tissues. Life Sci. 2011 88:798-802

5.Nakajima K, Wu G, Takeyama N, Sakudo A, Sugiura K, Yukawa M, and Onodera T. IA-2-deficient mice developed severe forms of diabetes induced by multiple low doses of streptozotocin. Int J Mol Med 2009 24:23-7

6.Takeyama N, Ano Y, Wu G, Kubota N, Saeki K, Sakudo A, Momotani E, Sugiura K, Yukawa M, and Onodera T. Localization of insulinoma associated protein 2, IA-2 in mouse neuroendocrine tissues using two novel monoclonal antibodies. Life Sci. 2009 84:678-87

7.Wu G, Nakajima K, Takeyama N, Sakudo A and Onodera T. Species-specific anti-apoptotic activity of cellular prion protein in a mouse PrP-deficient neuronal cell line transfected with mouse, hamster, and bovine Prnp. Neurosci Lett 2008 446:11-5

8.Yagi S, Hirabayashi K, Sato S, Li W, Takahashi Y, Hirakawa T, Wu G, Hattori N, Hattori N, Ohgane J, Tanaka S, Liu X. S, and Shiota K. DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res 2008 18:1969-78

9.Hosokawa T, Tsuchiya K, Sato I, Takeyama N, Ueda S, Tagawa Y, Kimura KM, Nakamura I, Wu G, Sakudo A, Casalone C, Mazza M, Caramelli M, Takahashi H, Sata T, Sugiura K, Baj A, Toniolo A,and Onodera T. A monoclonal antibody (1D12) defines novel distribution patterns of prion protein (PrP) as granules in nucleus.　Biochem Biophys Res Commun 2008 366:657-63.

10.Sakudo A, Wu G, Onodera T, and Ikuta K. Octapeptide repeat region of prion protein (PrP) is required at an early stage for production of abnormal prion protein in PrP-deficient neuronal cell line. Biochem Biophys Res Commun. 2008 365:164-9.

11.Kawakami T, Saeki K, Takeyama N, Wu G, Sakudo A, Matsumoto Y, Hayashi T, and Onodera T.Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies. Int J Mol Med. 2007 20:177-85.

12.Onodera T, Sakudo A, Wu G, and Saeki K. Bovine spongiform encephalopathy in Japan: history and recent studies on oxidative stress in prion diseases. Microbiol Immunol. 2006 50:565-78.